Michigan State University College of Human Medicine Department of Family Medicine

Reduce Workplace Violence in Hospitals

Background: Violence towards health care workers is a significant occupational hazard that threatens employee safety, health, work productivity, retention, and the quality of care. Violent acts, most of which are attributed to patients and patient visitors, contribute to a dangerous and unhealthy work environment for the nation’s 6.5 million hospital workers. However, hospitals lack practical […]

SmartCare: Innovations in caregiving interventions

Abstract: Multiple studies have shown that the psychological and physical consequences of providing care to a family member with a chronic illness can include anxiety, depressive symptoms, burden, altered immune function, poor overall health, and increased overall mortality. Family caregivers of persons with a primary malignant brain tumor (PMBT) are at particular risk for poor […]

Developing Bayesian methods for non-inferiority trial in comparative effectiveness

Summary: In this proposal we will focus on two aspects primarily, a) Eliciting prior information from heterogeneous sources such as past similar clinical trials from patients/clinicians/stakeholders opinion; and b) Incorporating this prior in both two-arm and three-arm NI trial design. In a three-arm NI trial when it is ethically acceptable a placebo arm is added […]

Neurofibrillary Tangle Evolution in Mild Cognitive Impairment

Abstract: The cerebral mantle receives a massive cholinergic innervation from AD-vulnerable neurons located within the nucleus basalis of Meynert (NBM; Ch4). The magnitude of Ch4 neuronal loss in AD is apparent in regional variations with the greatest loss in the posterior division (Ch4p), followed by the intermediate division (Ch4i), with the least affected being the […]

Mental Health in Iraqi Refugees

The importance of post-displacement social stressors and institutional resources The major goal of this 5-year prospective controlled community-based participatory cohort study is to determine the importance of post-displacement social-environmental stressors and institutional resources for health and social and vocational integration in a random sample of Iraqi refugees as compared to immigrant controls.

Developing Bayesian methods for non-inferiority trial in comparative effectiveness

In this proposal we will focus on two aspects primarily, a) Eliciting prior information from heterogeneous sources such as past similar clinical trials from patients/clinicians/stakeholders opinion; and b) Incorporating this prior in both two-arm and three-arm NI trial design. In a three-arm NI trial when it is ethically acceptable a placebo arm is added along […]

Neurofibrillary Tangle Evolution in Mild Cognitive Impairment

The cerebral mantle receives a massive cholinergic innervation from AD-vulnerable neurons located within the nucleus basalis of Meynert (NBM; Ch4). The magnitude of Ch4 neuronal loss in AD is apparent in regional variations with the greatest loss in the posterior division (Ch4p), followed by the intermediate division (Ch4i), with the least affected being the anteromedial […]